Cascades to Coast

Can chemists make compounds in the lab that are less common in nature?

Chemists not only can do it, they love to do it. There have been
over 4 million organic compounds officially registered and about
100,000 more are added every year. I'd estimate that most of those
are compounds that do not occur naturally at all. Chemists have
available a variety of high-energy reagents and conditions and
catalysts that are not possible in nature, and these can be used to
force molecules into unusual and unstable forms that could not occur
naturally. A very simple example would be the formation of metallic
sodium by electrolysis.

Quoting from Wikipedia:
Elemental sodium was first isolated by Humphry Davy in 1807 by
passing an electric current through molten sodium hydroxide.
Elemental sodium does not occur naturally on Earth, because it
quickly oxidizes in air[2] and is violently reactive with water, so
it must be stored in a non-oxidizing medium, such as a
liquid hydrocarbon. The free metal is used for some chemical
synthesis, analysis, and heat transfer applications.
The converse is that Mother Nature has also made millions of
different compounds, most of which chemists can't make in the lab
(though many chemists try to make some of the simpler and more
interesting molecules).